Joseph W Lynch Selected Research

Ligand-Gated Ion Channels

10/2014	The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine.
11/2013	New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms.
7/2010	Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia.

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Joseph W Lynch Research Topics

Disease

12	Hyperekplexia 01/2018 - 04/2010
10	Pain (Aches) 01/2018 - 10/2004
9	Epilepsy (Aura) 04/2022 - 01/2009
3	Autism Spectrum Disorder 01/2022 - 01/2017
3	Nervous System Diseases (Neurological Disorders) 01/2017 - 08/2012
2	Stroke (Strokes) 01/2017 - 01/2015
2	Inflammation (Inflammations) 04/2015 - 10/2013
2	Stiff-Person Syndrome (Stiff Man Syndrome) 04/2012 - 01/2011
1	Proteostasis Deficiencies 01/2021
1	Malaria 01/2020
1	Neurodevelopmental Disorders 01/2020
1	Febrile Seizures (Febrile Seizure) 12/2017
1	Paralysis (Palsy) 10/2017
1	Starvation 10/2017
1	Brain Ischemia (Cerebral Ischemia) 01/2017
1	Intractable Pain 01/2017
1	Ischemic Stroke 01/2017
1	Acidosis 01/2017
1	Pathologic Processes 11/2015
1	Sleep Initiation and Maintenance Disorders (Insomnia) 07/2015
1	Acquired Immunodeficiency Syndrome (AIDS) 07/2015
1	Status Epilepticus (Complex Partial Status Epilepticus) 04/2015
1	Schizophrenia (Dementia Praecox) 01/2015
1	Amnesia (Dissociative Amnesia) 01/2015
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2015
1	Down Syndrome (Down's Syndrome) 01/2015
1	Dementia (Dementias) 01/2015
1	Alzheimer Disease (Alzheimer's Disease) 10/2014
1	Chronic Pain 08/2014
1	Tobacco Use Disorder (Nicotine Dependence) 08/2014
1	Movement Disorders (Movement Disorder) 01/2009

Drug/Important Bio-Agent (IBA)

14	Glycine Receptors (Glycine Receptor)IBA 01/2018 - 01/2006
5	Pharmaceutical PreparationsIBA 01/2021 - 01/2009
4	Ion Channels (Ion Channel)IBA 04/2022 - 11/2015
3	Protein Isoforms (Isoforms)IBA 12/2017 - 01/2009
3	Ligand-Gated Ion ChannelsIBA 10/2014 - 07/2010
2	gamma-Aminobutyric Acid (GABA)IBA 04/2022 - 12/2017
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2022 - 10/2013
2	Biological ProductsIBA 01/2020 - 03/2013
2	Ivermectin (Mectizan)FDA Link 01/2020 - 08/2012
2	Anticonvulsants (Antiepileptic Drugs)IBA 12/2017 - 04/2015
2	ChloridesIBA 10/2017 - 01/2016
2	ProstaglandinsIBA 01/2017 - 10/2013
2	Analgesics (Analgesic Drugs)IBA 10/2013 - 10/2004
2	DNA (Deoxyribonucleic Acid)IBA 04/2013 - 07/2010
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	Dihydroergocristine FDA LinkGeneric 01/2021
1	DinoprostIBA 01/2021
1	fipronilIBA 01/2020
1	glutamate-gated chloride channelsIBA 01/2020
1	Hexachlorocyclohexane (gamma-Hexachlorocyclohexane)FDA LinkGeneric 01/2020
1	CationsIBA 01/2020
1	InsecticidesIBA 01/2020
1	PicrotoxinIBA 01/2020
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2020
1	LigandsIBA 01/2018
1	AnionsIBA 01/2018
1	Vorinostat FDA Link 01/2018
1	Carbamazepine (Tegretol)FDA LinkGeneric 12/2017
1	Midazolam (Versed)FDA LinkGeneric 12/2017
1	AcidsIBA 01/2017
1	Acid Sensing Ion ChannelsIBA 01/2017
1	DisulfidesIBA 01/2017
1	DNA Transposable Elements (Element, IS)IBA 01/2017
1	Peptides (Polypeptides)IBA 01/2017
1	Spider Venoms (Venom, Spider)IBA 01/2017
1	Zolpidem (Ambien)FDA LinkGeneric 07/2015
1	BenzodiazepinesIBA 07/2015
1	Eszopiclone (Lunesta)FDA Link 07/2015
1	Anaphylatoxin C5a ReceptorIBA 04/2015
1	Complement Receptors (Complement Receptor)IBA 04/2015
1	Kainic Acid (Kainate)IBA 04/2015
1	Complement System Proteins (Complement)IBA 04/2015
1	Pilocarpine (Ocusert)FDA LinkGeneric 04/2015
1	Anesthetics (Anesthetic Agents)IBA 01/2015
1	Memantine (Namenda)FDA Link 10/2014
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 08/2014
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 08/2014
1	Glycine Plasma Membrane Transport ProteinsIBA 03/2013
1	AnthelminticsIBA 08/2012
1	Chloride Channels (Chloride Channel)IBA 01/2011
1	Retinaldehyde (Retinal)IBA 01/2009

Therapy/Procedure

3	Therapeutics 01/2017 - 04/2010
1	Immunomodulation 01/2009